Prosthetic rehabilitation of patients after surgical and adjuvant treatment of craniofacial region tumors is challenging for both the clinician and the dental technician. Extensive surgical procedures and unfavorable tissue conditions limit the possibilities of prosthetic treatment. Edentulous patients who have undergone maxillary resection due to cancer and require obturator prostheses also pose a significant challenge. This paper describes a case of a patient with an edentulous maxilla for whom a 3D-printed hollow bulb obturator, detachable from the denture, was fabricated.