Multilayer zirconia ceramics with a high yttrium content represent an important step in the development of zirconia-based materials, improving the aesthetics of full-contour restorations while maintaining acceptable mechanical properties. The aim of this study was to review the literature on the types of multilayer ceramics currently available on the market, the influence of their composition on mechanical and optical properties, and clinical application, with comparison to monolayer 3Y-TZP and lithium disilicate. Publications from 2018–2026 available in Medline via PubMed, Scopus, Web of Science, and Polish dental journals were analyzed, with 31 studies ultimately included in the review. A significant difference was demonstrated between multilayer zirconia with a color gradient and materials with a yttria-content gradient. Increasing the yttria content improves the translucency and optical properties of the material however, it is associated with a decrease in mechanical strength, particularly in enamel layers. Nevertheless, more durable cervical layers influence zirconia with a translucency gradient to have better mechanical properties than multilayer zirconia with constant high translucency. Ceramics with yttria and translucency gradient allow better reproduction of the optical characteristics of dental tissues than monolayer materials, although their aesthetics are still inferior to those of lithium disilicate. Proper positioning of the restoration within the disc, selection of material thickness, adherence to sintering recommendations, and final surface finishing are of key clinical importance. Multilayer zirconia represents a compromise between aesthetics and strength, and its application requires consideration of differences in the properties of individual layers as well as potential weakening at their interfaces.