The most common cancer of the floor of the mouth is squamous cell carcinoma. The pathogenesis of this neoplasm is complex, but stimulants, HPV infection, trauma, poor oral hygiene, and precancerous conditions such as leukoplakia, erythroplasia and lichen planus all play a significant role. Males aged between 50 and 70 years are more likely to be affected. The most common symptom reported by patients is the appearance of a painless prominence or a non-healing ulcer, breathing and swallowing problems. Surgical procedures performed in the oral cavity due to cancer often leave functional and aesthetic defects. This case report concerns a patient who underwent interdisciplinary removal of part of the tongue and floor of the mouth, and restoration of chewing and speaking functions. Due to inadequate bone conditions and the patient’s weakness, implant-supported dentures were not considered; instead, full upper and lower dentures were fabricated. After prosthetic reconstruction, the patient was instructed to perform exercises to strengthen the masticatory muscles and to attend for periodic follow-up visits.