An implant-retained complete lower denture is widely recognized as the gold standard for rehabilitating the edentulous mandible. Its simplicity, minimal invasiveness, predictability, efficacy, and cost-effectiveness make it an attractive treatment option. The most commonly used retention systems for overdentures include bars and axial attachment systems. Clinicians must carefully evaluate the advantages and limitations of each system to determine the most appropriate choice based on the clinical context. This work presents two clinical cases of edentulous patients rehabilitated with implant-supported overdentures retained by Locator attachments. In the first case, Locators were selected due to implant axis divergence, necessitating a retention system that compensates for angulation discrepancies while ensuring optimal prosthetic stability. In the second case, Locator attachments were selected due to limited interocclusal space, requiring a low-profile retention system to maintain functionality and esthetics. These cases highlight the importance of individualized treatment planning based on anatomical and biomechanical considerations. The Locator system offers advantages including self-alignment during insertion, a compact design, and the ability to accommodate implant angulations of up to 40 degrees. Compared to ball attachments, Locators exhibit greater durability and maintain retention force over time, making them a superior choice in cases of implant divergence or restricted interocclusal space.