Prosthetic rehabilitation of patients after maxillofacial surgery is extremely difficult due to atypical conditions of the prosthetic base. These operations involve extensive tissue loss, morphological, functional, and aesthetic disorders within the entire stomatognathic system. The article presents the prosthetic treatment of a patient diagnosed with melanoma of the maxillary sinus and nasal cavity after surgical treatment (resection of the right maxilla with orbital exenteration). The primary goal of reconstructive treatment is to restore the natural appearance of the face, basic physiological activities such as chewing, swallowing, speech, and breathing, as well as to improve the mental condition of patients. Clinical management is often burdened with difficulties. Dentures equipped with an obturator are designed to close the communication between the oral cavity, maxillary sinuses, and the nasal cavity and to separate the oral flora of these spaces and fill the postoperative cavity to provide support for the face, mouth, and cheeks and to reconstruct missing teeth. Ectoprostheses reconstruct the lost tissues of the face and its contours with a satisfactory aesthetic effect, improving the patient’s wellbeing. Aesthetic rehabilitation is a very important aspect in improving the mental state of patients. All of these factors play a fundamental role in improving the health-related quality of life.