Acrylic resin remains the primary material used in the fabrication of removable prostheses, despite the continuous development of prosthetic materials science. The nature of the material’s composition requires frequent hygienic procedures and occasional disinfection, typically employing chemical agents. This paper presents methods for conducting disinfection of prosthetic components. The first method involves utilization of microwaves generated by a household microwave oven. Through its thermal and non-thermal effects, microwaves eliminate microorganisms from the surface and the body of the acrylic material. Numerous studies confirm the effectiveness of microwaves in the treatment of prosthetic stomatitis. Another method is photodynamic therapy, which entails applying a light-sensitive chemical solution (photosensitizer) to the prosthesis’ surface and then irradiating it using a lamp with an appropriate wavelength spectrum. Light, by activating the photosensitizer, leads to the elimination of microorganisms through the generation of active oxygen species. In clinical practice, achieving the desired antimicrobial effect may require combining this method with another one. The last agent on the list that is suitable for prosthesis’ disinfection is electrolyzed water. It is produced by the electrolysis of table salt water solution. Applied voltage on the electrodes induces a series of electrochemical reactions, resulting in a weak solution of sodium hypochlorite with a high redox potential. This method is safe, cost-effective, and environmentally friendly.