Temporomandibular disorders (TMD) it is a term used for a set of disorders, whose symptoms include, among others, face and neck muscle pain, temporomandibular joint (TMJ) pain, acoustic symptoms in TMJ, and derange pattern and range of movement.. At some point in their life, even 50-75% of the population may be afflicted by these disorders. . The etiology of TMD is not fully known. TMD occurrence is determined by factors such as congenital, emotional or external factors. The purpose of this article is to explore the information contained in scientific literature on TMD as a medical condition that occurs in the course of many diseases and may accompany some systemic disorders. It has to be remembered that this disorder may not function as a separate disease entity but be a symptom of other conditions. The article deals with, inter alia, TMD coexistence with headache, especially of migraine origin, correlation between rheumatic diseases or stress, and functional disorders of the temporomandibular joints. Its main objective is to to broaden the knowledge, suggest treatment methods in such cases and promote a holistic approach to treatment.