According to epidemiological data, the incidence of head and neck cancers in Poland remains consistently high. Radiotherapy is one of the basic methods of treating people affected by these diseases. Despite the progress in therapy, irradiation is still burdened with a high risk of complications wihin the stomatognathic system. The most serious ones include mucositis, decreased salivary secretion with all its consequences and osteoradionecrosis. Often, they contribute to long-term suffering of patients, leading to a significant reduction in their quality of life. In order to effectively prevent the occurrence of the above-mentioned complications, the oral cavity should be properly prepared prior to the irradiation procedure. Based on the literature and experience of the authors, the article presents suggestions for these preparation stages, taking into account the specific characteristics of the basic therapy.