Neuropathy of the inferior alveolar nerve (IAN) is usually associated with the field of oral surgery, and complications during dental procedures involving reversible nerve damage are relatively common (8.5-37%). Compression neuropathy may also occur, which constitutes a significant problem in prosthetic treatment, especially in the case of edentulous patients utilizing removable dentures in the mandible. Atrophy of the alveolar part of the mandible may occur either due to underloading (non-use of prosthetic appliances) or overloading (uneven force transmission through the denture), leading to pathological bone remodeling and accelerated resorption. This paper describes a case of a 71-yearold female patient referred to the Department of Prosthodontics due to pain characteristic of inferior alveolar nerve neuralgia on the left side. Due to significant atrophy of the alveolar processes of the mandible, the patient was provided with a complete set of dentures at the same time relieving areas most susceptible to pressure. Prosthetic rehabilitation of patients with IAN or its branch neuralgia requires an individualized approach, meticulous clinical examination and proper planning of procedures undertaken in order to achieve the desired therapeutic outcomes. These primarily include: ensuring stabilization and retention during denture settling, protecting anatomical structures, preventing the formation of painful pressure sores and stomatopathy, protecting neurovascular bundles from compression, and thereby eliminating symptoms such as neuralgia, paresthesia, dysesthesia or hypoesthesia.