Immediate prosthetic restorations that are placed on the prosthetic foundation immediately after tooth extraction allow the patient to avoid a period of edentulism and related aesthetic and functional problems. Conventional methods of immediate dentures fabrication involve several clinical and laboratory procedures liable to human error. The use of digital technology during prosthetic rehabilitation simplifies procedural methods, reduces prosthetic manufacturing time, improves communication with the prosthetic laboratory, and achieves more predictable treatment outcome. The article presents a case report of a cancer patient with drug-induced bone necrosis, who required extraction of all the teeth in the maxilla and removal of bone necroses. The virtual model of the patient’s maxilla obtained from an intraoral scan (Trios 3, 3Shape, Denmark) was developed in Blue Sky Plan 4 software (Blue Sky Bio, USA), according to the planned scope of the surgical procedure. Next, the maxillary and mandibular models were printed in an Asiga Max UV 385 printer (Asiga, Australia) from DentaModel (Asiga, Australia) with guides to fix the registered spatial position of the dental arches in centric occlusion, and an immediate complete upper denture was fabricated conventionally.