Facial tissue defects can result from surgical treatment of tumours, congenital defects, trauma or infections. Due to the complex anatomy of the facial part of the skull, treating tissue defects in this region is complicated and requires the cooperation of specialists from various fields. The main objective in the rehabilitation of patients in this group is to restore facial aesthetics and the quality of life, which can be achieved through surgical reconstruction, prosthetic rehabilitation, or a combination of both. Epitheses constitute a non-invasive alternative to surgical procedures to restore missing tissue. Conventional procedures for manufacturing facial prostheses involve several complex clinical and laboratory stages, are uncomfortable for the patient and the success of treatment depends largely on the skills and experience of the team of doctors and technicians. Progress in the area of facial prosthetics requires a reduction of production costs, shorter production times, improved comfort and increased accessibility for patients. Computeraided design and manufacturing have offered new possibilities for the rehabilitation of patients with facial tissue defects. The development of digital technologies enables the simplification of complicated procedures and the manufacturing of customized prostheses for each patient.