Silver compounds have been used in many areas of everyday life for years. Silver nanoparticles (Ag-NPs) are structures whose size does not exceed 100 nm. Their structure ensures a high surface-to-volume ratio, which translates into favourable physicochemical properties of nanoparticles at small concentrations of silver. Their antimicrobial activity, discovered many years ago, enabled their application to medicine, too. Apart from their antibacterial, antifungal and antiviral activity, they also have anti-inflammatory effects and stimulate wound healing, which is an additional asset in dentistry. The literature on prosthetic dentistry shows the usage of silver nanoparticles, among others, in making plates of removable dentures, composite materials, bonding agents, in ceramics and dental implants’ surfaces. The main objective behind their use in dentistry is that they limit the formation of biofilm on the surface of the material that contains them. Besides many advantages of using silver nanoparticles, we have to bear in mind the limitations and threats related to their accumulation in the human body, which is the subject of ongoing r esearch.