The aim of the study was to present prosthetic treatment of the patient suffering from temporomandibular disorders and lateral functional mandibular dislocation. After initial diagnostics, physical examination of the patient and the interview, panoramic x-ray and a CBCT scan of temporomandibular joints were taken. The Cone Beam Computed Tomography (CBCT) scan enables diagnosing the location of mandibular heads in temporomandibular joint (TMJ). The therapy was initiated with the patient being treated with physiotherapy. In order to perform the deprogramming procedure a NTI splint was used for 1.5 months, three times a day for 1.5 hours in a natural position. In preparation for the prosthetic treatment, the sources of the infection were eliminated. Implants were placed. Deprogramming with the use of Sliding Guide was performed. Then the models were fixed in an articulator in the centric relation. Wax-up was performed. On its basest a mockup was prepared. Temporary appliances were used for three months. After this period, the final prosthetic appliances such as veneers, overdenture, bridge and implant crowns were made. By deprogramming and establishing the centric relation, stable occlusion can be achieved. The nine-year observation period has proven that the prosthetic appliances have not been damaged.